Best Infrastructure AI Startups in United States
100 startups match both filters.
Hugging Face
The AI community building the future of machine learning.
Lila Sciences
Building scientific superintelligence and autonomous AI labs for life, chemical and materials sciences.
Quantinuum
World's largest integrated quantum computing company
Anyscale
Production-scale AI infrastructure powered by Ray for distributed training, data curation, and batch inference.
Liquid AI
Efficient general-purpose foundation models built for edge, on-device, and cloud deployment at every scale.
DataRobot
The only unified agent workforce platform built for enterprise outcomes, not endless pilots.
Lightmatter
Photonic chips that move data with light for next-gen AI data centers
7AI
Agentic cybersecurity platform deploying autonomous AI security agents for alert triage and investigation.
Baseten
Deploy and scale AI models in production with the fastest inference infrastructure.
Positron AI
US-built, energy-efficient AI inference chips designed to challenge Nvidia on performance-per-watt.
Unconventional AI
Reinventing the computer with brain-inspired, energy-efficient AI hardware
TensorWave
AI cloud built on AMD Instinct accelerators, operating one of the world's largest liquid-cooled AMD GPU deployments.
EnCharge AI
Analog in-memory AI chips that slash energy use for inference
Databricks
VerifiedThe data + AI company
Fireworks AI
VerifiedProduction-grade generative AI serving
GridCARE
Physics-based AI that unlocks hidden power-grid capacity to accelerate AI data centers
Qualified Health
Enterprise generative AI infrastructure and governance for health systems
Figure AI
VerifiedGeneral-purpose humanoid robots
Modal
High-performance AI infrastructure with sub-second cold starts and instant autoscaling.
Parasail
Pay-per-token AI inference supercloud that puts developers in control
MatX
Chips built from the ground up for frontier large language models
You.com
The productivity search engine with AI agents.
Together AI
VerifiedThe open AI cloud
VAST Data
Unifying software layer for AI infrastructure
/dev/agents
An operating system purpose-built for the era of AI agents.
Mem0
The memory layer for AI agents and personalized AI applications
OpenRouter
A unified API gateway to 400+ LLMs across 60+ providers
DeepInfra
High-throughput, low-cost AI inference cloud
Eridu
Rebuilding the AI data center network to break the interconnect wall
Parallel
Web search and research API purpose-built for AI agents
Inferact
Commercial inference engine from the creators of vLLM
Story Protocol
Programmable IP blockchain for tracking and monetizing AI-era content
Exa
VerifiedSearch for AI applications
Tenstorrent
Tenstorrent provides high-performance AI compute solutions, from cards and workstations to scale-out servers, powered by flexible, open-source IP.
SambaNova
The fastest AI inference platform, purpose-built for agentic AI with custom dataflow technology and three-tier memory architecture.
GMI Cloud
AI-native inference cloud built for production AI workloads on H100, H200 and Blackwell GPUs.
io.net
Decentralized GPU cloud network aggregating compute for AI and ML workloads
Emerald AI
Turns AI data centers into flexible grid assets that ease power demand
SF Compute
A real-time marketplace for AI compute
Groq
VerifiedFastest AI inference on the planet
RadixArk
Open infrastructure for frontier AI, built on SGLang
Runloop
Enterprise-grade cloud infrastructure and devboxes for AI coding agents
FriendliAI
Fast, cost-efficient generative AI inference for any model
Hyperbolic
Open-access AI cloud for compute and inference
Cerebras Systems
VerifiedWafer-scale AI chips for unprecedented speed
Pinecone
VerifiedThe vector database for AI
Genmo
Open-source generative AI for video, building state-of-the-art text-to-video foundation models.
KERNEL
Crazy fast, open source infra for AI agents to use the Internet
Luminal
Making AI run fast on any hardware
Chalk
AI data platform delivering real-time context for models and agents
Native
Security-by-design control plane for multi-cloud and AI infrastructure
Lamini
Enterprise platform for tuning and running custom LLMs
Upscale AI
Pure-play AI networking infrastructure
Ragie
Fully managed RAG-as-a-Service for developers
Reactor
Real-time AI video generation with near-zero time to first frame
Manufact (formerly mcp-use)
Open source SDK & cloud infrastructure for MCP Servers & ChatGPT Apps
MemryX
Energy-efficient edge AI accelerator chips for on-device inference
Anon
Authentication and automation infrastructure so AI agents can act on the web
Scale AI
VerifiedData labeling and AI infrastructure platform powering frontier models for enterprises and governments.
Lambda
VerifiedGPU cloud for AI teams
Crusoe
VerifiedSustainable AI cloud infrastructure
Standard AI
Computer vision for autonomous checkout in physical retail.
truthsystems
Automatically blocking risky behavior with real-time governance agents
Replicate
VerifiedRun AI models in the cloud
Skyflow
Skyflow provides runtime AI data control, securing sensitive data across datastores, models, and AI agents.
Coval
Simulation and evaluation platform for voice and chat AI agents, modeled on self-driving car testing.
Dedalus Labs
Compute substrate for AI agents
AgentMail
Email Inboxes for AI Agents
Era
Software platform powering a new generation of AI gadgets and devices
BentoML
Unified inference platform to run AI at scale
LanceDB
AI-native multimodal lakehouse for vector search, training data, and retrieval.
Mercor
Mercor is an AI-powered platform connecting top-tier remote AI talent with companies shaping the future of artificial intelligence.
CoreWeave
The Essential Cloud for AI, purpose-built to power pioneers' most complex workloads with next-generation infrastructure and intelligent tools.
Higgsfield AI
Cinematic AI video + image — one chat, 30+ models, zero tool-hopping.
Terminal Use
Vercel for background agents
Sponge
Financial infrastructure for the agent economy
ProjectX
Infinity: the first OS where humans and agents work with no limits
SF Tensor
Infrastructure for AI labs to focus on research
Vana
Decentralized network for user-owned data to train AI models
Ndea
Frontier AI lab building AGI through deep learning-guided program synthesis.
Chamber
The AIOps Agent for ML Teams
Rubric AI
Reasoning and verification infra for AI
Moda
The monitoring layer your AI agents need
IncidentFox
AI SRE agent that triages, coordinates, and fixes production incidents
Orthogonal
Agentic Payments for APIs
RunAnywhere
The default way of running on-device AI at Scale
Klaus AI
Fast and Safe OpenClaw on the cloud
Captain
Give AI agents accurate knowledge search that scales
Autumn AI
Stalk your prospects at scale
Minicor
RPA platform for deploying AI into legacy desktop systems
InsForge
The agent-native cloud infrastructure platform
Interfaze
AI model built for deterministic developer tasks
StableBrowse
Browser Layer for AI agents
Wato
Shared memory, tools, and workflows for agents across teams
GovGuard
AI Infrastructure for Government Agencies
Hyperspell
Memory for AI Agents
Sciloop
Expert STEM reasoning data for frontier AI labs
Modelence
The full-stack platform for agentic development
LLM Stats
Independent AI evaluations lab
Neurophos
Metasurface optical processors for exaflop-scale AI inference