Thesis is an applied AI research lab automating AI research and development. The company aims to help researchers discover breakthroughs like AlphaFold or the Transformer faster, more systematically and at scale by treating scientific discovery as a combinatorial search problem. Thesis has reported state-of-the-art results on OpenAI's MLE-Bench, which tests how well AI systems can autonomously train machine learning models. It is based in San Francisco and is part of Y Combinator's Fall 2025 batch.
Thesis
ActiveAutomate AI research
Total raised
$500K
1 round
Stage
Seed
Jan 2025
Team
1-10
since 2025
Pricing
—
Founded
2025
San Francisco, United States
Agent-ready
—
Applied AI research lab automating AI research and development
Treats scientific discovery as a combinatorial search problem
Aims to systematize the path to breakthroughs like AlphaFold and the Transformer
Automated exploration of ML research directions at scale
Reported state-of-the-art results on OpenAI's MLE-Bench
Benchmark focus on autonomous ML model training
Designed to make discovery faster and cheaper
Research-driven, frontier-oriented approach
12/100
Early
MCP server
Public API
Webhooks
OAuth 2.0
SDKs
No public agent surfaces detected yet.
Jan 2025 Seed $500K ● Y Combinator
Capital network
$500K raised ·1 backer·10 network links
- Backers1
- Shared portfoliocompanies these backers also fund
- Extended networkfunds that co-invest alongside them
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- What is Thesis?
- Thesis is an applied AI research lab automating AI research and development, aiming to make scientific discovery faster and cheaper by treating it as a combinatorial search problem.
- What has Thesis demonstrated?
- Thesis has reported state-of-the-art results on OpenAI's MLE-Bench, which tests how well AI systems can autonomously train machine learning models.
- What is Thesis trying to achieve?
- Its goal is to help researchers reach breakthroughs like AlphaFold or the Transformer faster, more systematically, and at scale.
- Is Thesis a product or a lab?
- Thesis describes itself as an applied AI research lab based in San Francisco and part of Y Combinator's Fall 2025 batch, focused on automating AI R&D.
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