OpenEvidence vs Profluent
Which Healthcare AI tool is better in 2026?
OpenEvidence
AI medical assistant for clinicians
Profluent
Frontier AI models for programmable biology and protein design
Side-by-side
| OpenEvidence | Profluent | |
|---|---|---|
| Tagline | AI medical assistant for clinicians | Frontier AI models for programmable biology and protein design |
| Founded | 2022 | 2022 |
| HQ | San Francisco, US | Emeryville, US |
| Employees | 50-200 | 51-100 |
| Total funding | $735M | $150M |
| Latest round | Series D · Jan 2026 | Series B · Nov 2025 |
| Valuation | $12B | — |
| Cheapest paid plan | — | Pricing not disclosed |
| Free plan | ✓ Free for Verified US Physicians | ✗ |
| Free trial | ✗ | ✗ |
| Top tier price | — | Pricing not disclosed |
| Pricing summary | 1 published plans | Enterprise · Contact sales |
| Categories |
Capability matrix
Developer-facing capabilities and access signals for OpenEvidence and Profluent.
| Capability | OpenEvidence | Profluent |
|---|---|---|
| MCP support | ✗ | ✗ |
| Public API | ✓ | ✗ |
| Webhooks | ✗ | ✗ |
| OAuth 2.0 | ✗ | ✗ |
| SDK languages | 2 (TypeScript, Python) | — |
| Free plan | ✓ | ✗ |
| Free trial | ✗ | ✗ |
| Verified | ✓ | ✗ |
| Active deal | ✗ | ✗ |
🟢 Strengths of OpenEvidence
- Has raised more capital ($735M vs $150M)
- Higher Neuron score (60 vs 50)
- Offers a free plan
- Verified profile
🔵 Strengths of Profluent
- Strong in AI Healthcare
Which should you choose?
Choose Profluent if price matters most — it starts at Enterprise · Contact sales, which is friendlier for teams watching burn. Both AI Healthcare tools ship core features, so the cost delta often decides it for small teams and solo operators.
Choose OpenEvidence if you want the most established option — it has raised $735M, suggesting more runway for enterprise features, support, and long-term roadmap. For mission-critical workflows or larger teams, that stability often outweighs a lower monthly price.
Frequently asked questions
OpenEvidence vs Profluent — which is better?
It depends on your priority. OpenEvidence has raised more capital and is the more established option; Profluent is cheaper to start. See the side-by-side table above.
Is OpenEvidence cheaper than Profluent?
No — Profluent's cheapest paid plan is Enterprise · Contact sales, while OpenEvidence's is Free.
Do OpenEvidence and Profluent offer free plans?
OpenEvidence: Yes, has a free plan. Profluent: Paid only.
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