Astraea vs OpenEvidence
Which Healthcare AI tool is better in 2026?
Astraea
Agents that compress clinical trial biometrics from months to days.
OpenEvidence
AI medical assistant for clinicians
Side-by-side
OpenEvidence is the more established option (raised $735M); pricing is comparable on both sides.
| Metric | Astraea | OpenEvidence |
|---|---|---|
| Taglinei | Agents that compress clinical trial biometrics from months to days. | AI medical assistant for clinicians |
| Foundedi | 2025 | 2022🏆 |
| HQi | San Francisco, US | San Francisco, US |
| Employeesi | — | 50-200🏆 |
| Neuron scorei | 48 | 64🏆 |
| Total fundingi | $500K | $735M🏆 |
| Latest roundi | Seed · Mar 2026 | Series D · Jan 2026 |
| Valuationi | — | $12B🏆 |
| Cheapest paid plani | Pricing not disclosed | — |
| Free plani | ✗ | ✓ Free for Verified US Physicians |
| Free triali | ✗ | ✗ |
| Top tier pricei | Pricing not disclosed | — |
| Pricing summaryi | Contact-sales | 1 published plans |
| Categoriesi |
Capability matrix
Developer-facing capabilities and access signals for Astraea and OpenEvidence.
| Capability | Astraea | OpenEvidence |
|---|---|---|
| MCP support | ✗ | ✗ |
| Public API | ✗ | ✓ |
| Webhooks | ✗ | ✗ |
| OAuth 2.0 | ✗ | ✗ |
| SDK languages | — | 2 (TypeScript, Python) |
| Free plan | ✗ | ✓ |
| Free trial | ✗ | ✗ |
| Verified | ✗ | ✓ |
| Active deal | ✗ | ✗ |
🟢 Strengths of Astraea
- Newer company (2025)
🔵 Strengths of OpenEvidence
- Has raised more capital ($735M vs $500K)
- Higher Neuron score (64 vs 48)
- Offers a free plan
- More mature (2022)
Which should you choose?
Choose OpenEvidence if price matters most — it starts at Free, which is friendlier for teams watching burn. Both AI Healthcare tools ship core features, so the cost delta often decides it for small teams and solo operators.
Choose OpenEvidence if you want the most established option — it has raised $735M, suggesting more runway for enterprise features, support, and long-term roadmap. For mission-critical workflows or larger teams, that stability often outweighs a lower monthly price.
Frequently asked questions
Astraea vs OpenEvidence — which is better?
It depends on your priority. Astraea is the leaner option; OpenEvidence has broader feature depth. See the side-by-side table above.
Is Astraea cheaper than OpenEvidence?
No — OpenEvidence's cheapest paid plan is Free, while Astraea's is Contact-sales.
Do Astraea and OpenEvidence offer free plans?
Astraea: Paid only. OpenEvidence: Yes, has a free plan.
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